Joanna J Phillips Selected Research

alpha-hydroxyglutarate

8/2022	Spectroscopic imaging of D-2-hydroxyglutarate and other metabolites in pre-surgical patients with IDH-mutant lower-grade gliomas.
1/2020	Patient-derived cells from recurrent tumors that model the evolution of IDH-mutant glioma.
1/2018	2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas.
1/2018	Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner.
1/2017	Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma.
11/2016	Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process.
1/2015	Metabolic reprogramming in mutant IDH1 glioma cells.
5/2014	Characterization of metabolites in infiltrating gliomas using ex vivo ¹H high-resolution magic angle spinning spectroscopy.
1/2014	Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase.
1/2012	Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas.

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Joanna J Phillips Research Topics

Disease

81	Neoplasms (Cancer) 01/2022 - 06/2010
47	Glioma (Gliomas) 08/2022 - 01/2012
41	Glioblastoma (Glioblastoma Multiforme) 10/2022 - 06/2010
15	Astrocytoma (Pilocytic Astrocytoma) 08/2022 - 04/2011
13	Brain Neoplasms (Brain Tumor) 01/2021 - 06/2011
6	Medulloblastoma 01/2021 - 05/2012
4	Oligodendroglioma 01/2022 - 04/2013
4	Meningioma (Meningiomas) 01/2022 - 12/2016
4	Carcinogenesis 01/2022 - 01/2014
2	Chordoma 10/2017 - 02/2014
2	Disease Progression 01/2017 - 01/2016
2	Hypoxia (Hypoxemia) 08/2015 - 07/2012
1	Ependymoma 10/2021
1	Leukopenia 01/2021
1	Neutropenia 01/2021
1	Neuroepithelial Neoplasms (Gliomatosis Cerebri) 01/2020
1	Neurocytoma 01/2020

Drug/Important Bio-Agent (IBA)

17	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2022 - 01/2012
15	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2012
13	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2010
10	alpha-hydroxyglutarateIBA 08/2022 - 01/2012
9	Temozolomide (Temodar)FDA LinkGeneric 11/2021 - 06/2011
8	Choline (Choline Chloride)IBA 08/2022 - 11/2010
8	RNA (Ribonucleic Acid)IBA 10/2021 - 01/2013
8	Phosphotransferases (Kinase)IBA 01/2021 - 05/2012
7	Biological ProductsIBA 01/2022 - 12/2012
7	Histones (Histone)IBA 01/2020 - 04/2013
5	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2022 - 03/2012
5	Pharmaceutical PreparationsIBA 01/2021 - 06/2010
5	EnzymesIBA 01/2021 - 03/2012
5	Pyruvic Acid (Pyruvate)IBA 01/2021 - 06/2011
4	Protein Isoforms (Isoforms)IBA 07/2016 - 01/2013
4	Bevacizumab (Avastin)FDA Link 01/2016 - 07/2012
3	Inositol (Myoinositol)IBA 08/2022 - 11/2010
3	SulfatasesIBA 01/2022 - 03/2012
3	Heparitin Sulfate (Heparan Sulfate)IBA 01/2022 - 02/2015
3	Transcription Factors (Transcription Factor)IBA 11/2021 - 10/2017
3	palbociclibIBA 01/2021 - 11/2018
3	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 01/2018
3	ErbB Receptors (EGF Receptor)IBA 01/2019 - 07/2014
3	Phosphorylcholine (Phosphocholine)IBA 01/2018 - 04/2011
3	Glutamic Acid (Glutamate)FDA Link 01/2017 - 08/2014
2	VaccinesIBA 01/2022 - 12/2016
2	GlycosaminoglycansIBA 01/2022 - 11/2017
2	Proteoglycans (Proteoglycan)IBA 01/2022 - 05/2013
2	ChromatinIBA 11/2021 - 01/2017
2	Indicators and Reagents (Reagents)IBA 05/2021 - 05/2016
2	AcidsIBA 05/2021 - 05/2016
2	LigandsIBA 01/2021 - 05/2012
2	NucleotidesIBA 01/2021 - 01/2019
2	Retinoblastoma ProteinIBA 01/2021 - 01/2012
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 06/2011
2	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2021 - 12/2012
2	sapanisertibIBA 01/2020 - 02/2014
2	gamma-Aminobutyric Acid (GABA)IBA 11/2018 - 01/2017
2	N-acetoacetyl-N-deacetylcolchicineIBA 08/2018 - 12/2017
2	N-acetylaspartate (N-acetyl aspartate)IBA 08/2018 - 11/2010
2	Phospholipids (Phosphatides)FDA LinkGeneric 01/2018 - 01/2018
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 12/2017 - 01/2017
2	AntigensIBA 12/2016 - 01/2015
2	LuciferasesIBA 11/2016 - 12/2012
2	Pyruvate KinaseIBA 07/2016 - 01/2013
2	Messenger RNA (mRNA)IBA 01/2015 - 11/2013
2	Epidermal Growth Factor (EGF)IBA 01/2015 - 01/2015
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2014 - 07/2012
2	Protons (Proton)IBA 05/2014 - 01/2012
2	GadoliniumIBA 08/2013 - 07/2012
2	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 05/2012 - 03/2012
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2012 - 03/2012
1	Neurofibromin 2 (Merlin)IBA 01/2022
1	Chondroitin Sulfates (Chondroitin Sulfate)IBA 01/2022
1	poly ICLCIBA 01/2022
1	Cytostatic AgentsIBA 01/2022
1	Phospho-Specific AntibodiesIBA 01/2022
1	ChemokinesIBA 01/2022
1	Small Cytoplasmic RNAIBA 11/2021
1	CytokinesIBA 11/2021
1	Metformin (Glucophage)FDA LinkGeneric 10/2021
1	Hypoglycemic Agents (Hypoglycemics)IBA 10/2021
1	Tricarboxylic AcidsIBA 10/2021
1	Untranslated RNA (Noncoding RNA)IBA 01/2021
1	Carboxylesterase (Hydrolase S)IBA 01/2021
1	Cyclin-Dependent Kinase 4IBA 01/2021
1	Alanine (L-Alanine)FDA Link 01/2021
1	xylosidesIBA 01/2021
1	ProdrugsIBA 01/2021
1	MonosaccharidesIBA 01/2021
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2021
1	tyrosine receptor (receptor, tyrosine)IBA 01/2021
1	PP242IBA 01/2020
1	DNA Repair EnzymesIBA 01/2020
1	Ku 0063794IBA 01/2020
1	MethyltransferasesIBA 01/2020
1	2,6-dinitrotoluene (DNT)IBA 01/2020

Therapy/Procedure

30	Therapeutics 10/2022 - 06/2010
6	Drug Therapy (Chemotherapy) 11/2021 - 10/2016
6	Radiotherapy 11/2021 - 01/2016
4	Immunotherapy 01/2022 - 12/2016
2	Precision Medicine 10/2019 - 08/2015
2	Transplantation 01/2019 - 05/2012